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March 26, 2025
Breakthroughs in Dermatologic Care at the 2025 AAD Annual Meeting

The 2025 AAD Annual Meeting showcased key advancements in dermatologic care, including AI-driven innovations, novel therapies, and holistic patient management. Dr. Kathryn Schwarzenberger, MD, Professor of Dermatology at Oregon Health & Science University (OHSU) School of Medicine, and Dr. Linda Stein Gold, MD, FAAD, Director of Dermatology Clinical Research at Henry Ford Health System, led discussions on emerging treatment strategies. Dr. Stein Gold presented data from the ADORING 3 trial on tapinarof cream 1%, highlighting its steroid-free, long-term efficacy in atopic dermatitis, including pediatric patients.

Additional discussions covered lebrikizumab’s sustained benefits in moderate-to-severe atopic dermatitis and emerging evidence on IL-17/IL-23 inhibitors improving mental health in psoriasis. The conference emphasized technology’s role in transforming dermatology practice and the importance of interdisciplinary collaboration in patient care.

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April 16, 2023

Discussion: This retrospective cohort study of patients enrolled in the KPNC healthcare system addresses an important gap in the scientific literature by describing IRs of malignancies in patients with moderate and severe AD.

Rates of malignancies among patients with moderate to severe atopic dermatitis: a retrospective cohort study - PubMed

Rates of malignancies among patients with moderate to severe atopic dermatitis: a retrospective cohort study - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36898743/

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  • April 16, 2023
    While this subject clearly deserves further investigation, it is not surprising to learn about an increased incidence of malignancies such as NMSC and breast cancer in moderate to severe AD patients - since AD is an autoimmune disorder that is often treated with immunosuppressive traditional systemic and biologic agents.
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April 02, 2023
Strategies to Improve Adherence to Skin Self-examination and Other Self-management Practices in People at High Risk of Melanoma: A Scoping Review of Randomized Clinical Trials - PubMed

Strategies to Improve Adherence to Skin Self-examination and Other Self-management Practices in People at High Risk of Melanoma: A Scoping Review of Randomized Clinical Trials - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36857048/

Using an adaptation of the World Health Organization framework for clinical adherence, this scoping review of randomized clinical trials identified key concepts as well as gaps in the way adherence...

Discussion: Using an adaptation of the World Health Organization framework for clinical adherence, this scoping review of randomized clinical trials identified key concepts as well as gaps in the way adherence is approached in design, conduct, and reporting of trials for skin self-examination and other self-management practices in people at high risk of melanoma. These findings may usefully guide future trials and clinical practice; evaluation of adherence strategies may be possible using a Study Within A Trial (SWAT) framework within host trials.

  • April 02, 2023
    I offer full skin exams to every patient because they are so important. Yet despite how many melanomas I have incidentally diagnosed on patients during full skin exams who walk into the office with unrelated complaints, most melanomas are initially detected by patients themselves when noticing a new or changing mole upon self-examination. Therefore, self-exams are crucial and I tell every patient to do a skin self-exam every 3 months. It could save their lives.
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March 31, 2023
The Intestinal and Skin Microbiome in Patients with Atopic Dermatitis and Their Influence on the Course of the Disease: A Literature Review - PubMed

The Intestinal and Skin Microbiome in Patients with Atopic Dermatitis and Their Influence on the Course of the Disease: A Literature Review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36900771/

Bacteria inhabiting the digestive tract are responsible for our health. The microbiome is essential for the development of the immune system and homeostasis of the body. Maintaining homeostasis is very...

Conclusions/Relevance: Perhaps young children diagnosed with AD present specific characteristics of the intestinal microflora. This might be related to the early introduction of antibiotics and dietary manipulations in breastfeeding mothers in the early childhood of AD patients. It is most likely related to the abuse of antibiotics from the first days of life.

  • March 31, 2023
    This is an intriguing concept that definitely needs to be investigated further. GI microflora has clearly been implicated as a triggers for many autoimmune disorders.
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March 31, 2023
Noncutaneous and Cutaneous Cancer Risk in Patients With Atopic Dermatitis: A Systematic Review and Meta-analysis - PubMed

Noncutaneous and Cutaneous Cancer Risk in Patients With Atopic Dermatitis: A Systematic Review and Meta-analysis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/31825457/

Observational evidence suggests potential associations between AD and increased risk of keratinocyte carcinoma and kidney cancer as well as lower odds of lung and respiratory system cancers. Further research is...

Conclusion: Adults with moderate-to-severe AD had a significantly higher risk of developing melanoma (RR 1.11; 95% Cl, 1.05-1.17; p<.001), SCC (RR 1.25; 95% Cl, 1.22-1.28; p<.001), and BCC (RR 1.17; 95% Cl, 1.14-1.20; p<.001) compared to adults with mild AD. In conclusion, our findings support an increased risk of melanoma, SCC, and BCC development in adult patients with AD regardless of AD severity. More mechanistic studies are necessary to understand AD and the development of skin cancers.

  • March 31, 2023
    These results are consistent with the immune-mediated nature of both autoimmune diseases like AD and certain skin cancers. Also, moderate to severe AD patients may be more skin cancer prone due to increased UV exposure (natural or artificial) used in an attempt to ameliorate their AD symptoms.