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NB‐UVB phototherapy is associated with a reduction in topical corticosteroid and clinical improvement in atopic dermatitis - a historical inception cohort study

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between ..... see more

Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/ced.14676

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Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial

Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a high impact on the comfort of those who are affected and long-term treated with corticosteroids with limited efficacy ..... see more

Source : https://www.mdpi.com/2076-2607/9/4/854

Child with Atopic Dermatitis

A five-year-old male was being treated atopic dermatitis that started when he was a year old. Over time, the rash became worse and extremely itchy. ..... see more

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  • 1 day 15 hours
    I would take bacterial cultures of his worst areas, and start weekly bleach baths at 1 tsp/gallon. I would also encourage wet to dry pajamas at night, with triamcinalone Show More
  • 3 days 1 hour
    Start oral antibiotic, bleach baths followed by wet/ dry pjs with Eucerin eczema and Triamcinolone ointment mixture
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View our preview of the 2021 American Academy of Dermatology (AAD) Conference

Click on the icon above to preview and download our pre-conference coverage of the 2021 American Academy of Dermatology (AAD) Conference.

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from Dermatologist Nation made a Post

Do you give anti viral therapy to your severe atopic dermatitis patients prophylaxis

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Lifelong Impact of Severe Atopic Dermatitis on Quality of Life: A Case Report

Severe, uncontrolled atopic dermatitis (AD) persisting from childhood to adulthood can have enduring quality of life (QoL) impacts on daily functioning, academics, career, family and social life, and mental health. ..... see more

Source : https://link.springer.com/article/10.1007/s13555-021-00515-x

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Behavioral Modification for Acne Excoriée and Skin Picking

First published: This chapter aims to teach the basic principles of behavioral therapy for the aesthetic practitioner; this treatment modality is simple and structured, and requires minimal training to implement. ..... see more

Source : https://onlinelibrary.wiley.com/doi/abs/10.1002/9781119680116.ch21

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High dimensional analysis defines multicytokine T-cell subsets and supports a role for IL-21 in atopic dermatitis.

Background Flow cytometry is a well-accepted approach for immune profiling, however its value is restricted by the limited number of markers that can be analyzed simultaneously. Mass cytometry/CyTOFoffers broad-scale immune ..... see more

Source : https://europepmc.org/article/med/33818809

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Epidemiology and Characterization of Atopic Dermatitis in East Asian Populations: A Systematic Review

Introduction As atopic dermatitis (AD) grows increasingly prevalent in Asian populations worldwide, understanding how environmental, genetic, and cultural factors uniquely influence AD in Asians is essential for informing disease management. ..... see more

Source : https://link.springer.com/article/10.1007/s13555-021-00516-w

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Neutralization of IL-33 Modifies the Type 2 and Type 3 Inflammatory Signature of Viral Induced Asthma Exacerbation.

This preprint is under consideration at Respiratory Research. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not ..... see more

Source : https://doi.org/10.21203/rs.3.rs-271374/v1

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Neural Oscillation Associated with Contagious Itch in Patients with Atopic Dermatitis - PubMed

Patients with AD exhibited increased susceptibility to contagious itch. This phenomenon might be related to enhanced mu rhythm suppression in sensorimotor areas of the brain in these patients. Our findings ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33805350/

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IL-13 modulates ∆Np63 levels causing altered expression of barrier- and inflammation-related molecules in human keratinocytes: A possible explanation for chronicity of atopic dermatitis.

Background Barrier disruption and an excessive immune response in keratinocytes are now considered to have important roles in the pathophysiology of atopic dermatitis (AD). Furthermore, disturbed keratinocyte differentiation is considered ..... see more

Source : https://europepmc.org/article/med/33792188

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Dermatological Conditions in Skin of Color- Managing Atopic Dermatitis | JCAD | The Journal of Clinical and Aesthetic Dermatology

J Clin Aesthet Dermatol. 2021;14(3 Suppl 1):S20-S22 by Archana M. Sangha, MMS, PA-C Ms. Sangha is a Fellow of the American Academy of Physician Assistants and Diplomate and Current President ..... see more

Source : https://jcadonline.com/dermatological-conditions-skin-of-color-atopic-dermatitis/

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Anti-Inflammatory and Immune Modulatory Effects of Synbio-Glucan in an Atopic Dermatitis Mouse Model

Many trials have been conducted to treat atopic dermatitis (AD), but these therapies are generally unsuccessful because of their insufficiency or side effects. This study examined the efficacy of β-glucan ..... see more

Source : https://www.mdpi.com/2072-6643/13/4/1090

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JAK Inhibitors in Atopic Dermatitis

Atopic dermatitis (AD), also known as atopic eczema, is a chronic, pruritic, relapsing inflammatory dermatological condition. The exact cause of the disease is unknown; however, certain factors such as epigenetic, genetic, immunological, and environmental interactions with overlapping skin barrier defects are indicated in its pathogenesis.

Oral Janus kinase (JAK) inhibitors have been approved for use in treating patients with rheumatoid arthritis and other inflammation & immunity disorders. Signaling proteins linked to cytokine receptors activate transcription factors, called signal transducer and activator of transcription (STAT) and modulate the expression of thousands of genes associated with inflammatory processes. JAK inhibition of type 2 cytokine signaling has recently shown pruritic benefit in clinical trials. JAK inhibition is not restricted to systemic administration but has also been developed as a topical treatment option.

• Which clinical trial endpoints would be most impactful for you in assessing a drug’s efficacy for atopic dermatitis (ex. IGA, EASI, SCORAD, pruritus, QOL)?
• In what patient subset or severity would you consider using a JAK inhibitor?
• Would the availability of a topical JAK impact the prescribing trends for topical calcineurin inhibitors or crisaborole?


Reference: https://www.cell.com/action/showPdf?pii=S0092-8674%2817%2930931-5 

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Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review

Allergies are an increasing global public health concern, especially for children and people living in urban environments. Allergies impair the quality of life of those who suffer from them, and ..... see more

Source : https://doi.org/10.3390/foods10040701

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Transcriptomic insight into the translational value of two murine models in human atopic dermatitis

This study sought to develop a novel diagnostic tool for atopic dermatitis (AD). Mouse transcriptome data were obtained via RNA-sequencing of dorsal skin tissues of CBA/J mice affected with contact ..... see more

Source : https://www.nature.com/articles/s41598-021-86049-w