This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between ..... see more
Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a high impact on the comfort of those who are affected and long-term treated with corticosteroids with limited efficacy ..... see more
Severe, uncontrolled atopic dermatitis (AD) persisting from childhood to adulthood can have enduring quality of life (QoL) impacts on daily functioning, academics, career, family and social life, and mental health. ..... see more
First published: This chapter aims to teach the basic principles of behavioral therapy for the aesthetic practitioner; this treatment modality is simple and structured, and requires minimal training to implement. ..... see more
Background Flow cytometry is a well-accepted approach for immune profiling, however its value is restricted by the limited number of markers that can be analyzed simultaneously. Mass cytometry/CyTOFoffers broad-scale immune ..... see more
Introduction As atopic dermatitis (AD) grows increasingly prevalent in Asian populations worldwide, understanding how environmental, genetic, and cultural factors uniquely influence AD in Asians is essential for informing disease management. ..... see more
This preprint is under consideration at Respiratory Research. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not ..... see more
Patients with AD exhibited increased susceptibility to contagious itch. This phenomenon might be related to enhanced mu rhythm suppression in sensorimotor areas of the brain in these patients. Our findings ..... see more
Background Barrier disruption and an excessive immune response in keratinocytes are now considered to have important roles in the pathophysiology of atopic dermatitis (AD). Furthermore, disturbed keratinocyte differentiation is considered ..... see more
J Clin Aesthet Dermatol. 2021;14(3 Suppl 1):S20-S22 by Archana M. Sangha, MMS, PA-C Ms. Sangha is a Fellow of the American Academy of Physician Assistants and Diplomate and Current President ..... see more
Many trials have been conducted to treat atopic dermatitis (AD), but these therapies are generally unsuccessful because of their insufficiency or side effects. This study examined the efficacy of β-glucan ..... see more
JAK Inhibitors in Atopic Dermatitis
Atopic dermatitis (AD), also known as atopic eczema, is a chronic, pruritic, relapsing inflammatory dermatological condition. The exact cause of the disease is unknown; however, certain factors such as epigenetic, genetic, immunological, and environmental interactions with overlapping skin barrier defects are indicated in its pathogenesis.
Oral Janus kinase (JAK) inhibitors have been approved for use in treating patients with rheumatoid arthritis and other inflammation & immunity disorders. Signaling proteins linked to cytokine receptors activate transcription factors, called signal transducer and activator of transcription (STAT) and modulate the expression of thousands of genes associated with inflammatory processes. JAK inhibition of type 2 cytokine signaling has recently shown pruritic benefit in clinical trials. JAK inhibition is not restricted to systemic administration but has also been developed as a topical treatment option.
• Which clinical trial endpoints would be most impactful for you in assessing a drug’s efficacy for atopic dermatitis (ex. IGA, EASI, SCORAD, pruritus, QOL)?
• In what patient subset or severity would you consider using a JAK inhibitor?
• Would the availability of a topical JAK impact the prescribing trends for topical calcineurin inhibitors or crisaborole?
Allergies are an increasing global public health concern, especially for children and people living in urban environments. Allergies impair the quality of life of those who suffer from them, and ..... see more
This study sought to develop a novel diagnostic tool for atopic dermatitis (AD). Mouse transcriptome data were obtained via RNA-sequencing of dorsal skin tissues of CBA/J mice affected with contact ..... see more