A Topic Dermatitis-like Genodermatosis: Disease Diagnosis and Management
Source : https://www.mdpi.com/2075-4418/12/9/2177/html
Eczema is a classical characteristic not only in atopic dermatitis but also in various genodermatosis. Patients suffering from primary immunodeficiency diseases such as hyper-immunoglobulin E syndromes, Wiskott-Aldrich syndrome, immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome, STAT5B deficiency, Omenn syndrome, atypical complete DiGeorge syndrome; metabolic disorders such as acrodermatitis enteropathy, multiple carboxylase deficiency, prolidase deficiency; and other rare syndromes like severe dermatitis, multiple allergies and metabolic wasting syndrome, Netherton syndrome, and peeling skin syndrome frequently perform with eczema-like lesions.
Conclusion: A topic dermatitis-like lesions can frequently present in patients with genetic diseases. In this review, three main categories including immunological disorders, metabolic diseases, and rare syndromes are discussed. We have presented the diagnostic clues that simplify the differential diagnosis, especially for immunological disorders, shown herein.