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Treatment with phosphodiester CpG-ODN ameliorates atopic dermatitis by enhancing TGF-β signaling - PubMed

Treatment with phosphodiester CpG-ODN ameliorates atopic dermatitis by enhancing TGF-β signaling - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/33612150/

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG phosphorothioate (PS CpG-ODN) are known to decrease IgE synthesis in Th2 allergy responses. Nonetheless, the therapeutic role of PS CpG-ODN is limited due to cytotoxicity. Therefore, we developed a phosphodiester (PO) form of CpG-ODN ...