High dimensional analysis defines multicytokine T-cell subsets and supports a role for IL-21 in atopic dermatitis.

Source : https://europepmc.org/article/med/33818809

Background Flow cytometry is a well-accepted approach for immune profiling, however its value is restricted by the limited number of markers that can be analyzed simultaneously. Mass cytometry/CyTOFoffers broad-scale immune characterization integrating large number of parameters. While partial blood phenotyping was reported in atopic dermatitis (AD), patients' comprehensive profiling, critical for leveraging new targeted treatments, is not available.