Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36608129/
Atopic dermatitis (AD) is a chronic inflammatory skin condition increasing in industrial nations at a pace that suggests environmental drivers. We hypothesize that the dysbiosis associated with AD may signal...
Conclusion: While humans have only had approximately 10 generations to adapt to the industrial revolution and even fewer to the exposome of the last half century, commensal microbes have had over a million generations since 1950 alone. In this report, we propose a paradigm for research, which suggests that dysbiosis recapitulates...
Network pharmacology-based analysis to explore the therapeutic mechanism of Cortex Dictamni on atopic dermatitis
Dermatitis is a common clinical chronic inflammatory skin disease, which incidence has been on the rise in recent years. It not only seriously affects the physical and mental health of...
Conclusion: Cortex Dictamni can improve the symptoms of skin lesions and the degree of inflammation caused by AD, and may inhibit AD through multiple pathways, such as regulating PI3K-AKT and JAK1-STAT3/STAT6 pathways. These results not only provide experimental evidence for the clinical application of Cortex Dictamni but also provide some...
A fragment of type VI collagen alpha-6 chain is elevated in serum from patients with atopic dermatitis, psoriasis, hidradenitis suppurativa, systemic lupus erythematosus and melanoma - Scientific Reports
Source : https://www.nature.com/articles/s41598-023-28746-2
Extracellular matrix (ECM) remodeling of the skin is a continuous process necessary for maintaining tissue homeostasis. Type VI collagen (COL6) is characterized as a beaded filament, located in the dermal...
Conclusions: Cohort 2 confirmed C6A6 being upregulated in atopic dermatitis compared to healthy controls (p
Overall and Racial and Ethnic Subgroup Prevalences of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36857044/
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Conclusions: The findings of this cross-sectional study suggest that there is a significant burden of AA, AT, and AU in the US in which people of color, particularly Asian Americans, appear to be disproportionately affected.
Keratinocyte signaling in atopic dermatitis: investigations in organotypic skin models towards clinical application - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36841264/
A multitude of pathophysiological mechanisms contribute to atopic dermatitis (AD), the most common chronic inflammatory skin disease in the Western population. In the booming therapeutic market for AD, most small...
Discussion: Here, we highlight key evidence that keratinocytes represent major contributors to AD, including disease onset and progression through the physical, immunological and antimicrobial barrier functions of human skin. Examples are provided of pre-clinical skin models recapitulating features of AD in which keratinocyte-specific genetic,...