New Insight into Drugs to Alleviate Atopic March via Network Pharmacology-Based Analysis
Source : https://doi.org/10.3390/cimb44050153
In the present study, a subject of atopic dermatitis (AD) is exposed progressively to allergic rhinitis (AR) and asthma (AS), which is defined as atopic march (AM). However, both the...
The network analysis unveiled key targets against AM, and the MDT confirmed the affinity between significant compounds and targets. In this study, we described the significance of the eight uppermost targets (CCL2, CTLA4, CXCL8, ICAM1, IL10, IL17A, IL1B, and IL2) and eight ligands (Bindarit, CTLA-4 inhibitor, Danirixin, A-205804, AX-24 HCl,...
Longitudinal course and predictors of depressive symptoms in atopic dermatitis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35551964/
1 Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC USA. 2 Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL USA....
Conclusion: Depressive symptoms are closely related to and fluctuate with AD severity over time. Improved control of AD signs and symptoms, particularly itch, may secondarily improve mental health.
Conclusion This is the meaningful study to demonstrate that ECA improves allergic inflammation of the skin and lungs through recovery of the skin barrier, regulation of immune balance, and alleviation of lung inflammation, suggesting that ECA has therapeutic potential as an antiatopic and antiallergic agent that blocks the progression of AD to...
Gut microbiota and atopic dermatitis in children: a scoping review - BMC Pediatrics
Source : https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03390-3
Background Gut microbiota plays an important role in the development of atopic dermatitis (AD). We aimed to elucidate research trends in gut microbiota and AD in children, to provide evidence...
Conclusions: The changes of gut microbiota are essential to the development of AD in children, which may be an effective target for the prevention and treatment of AD. Future studies with larger sample size and rigorous design are needed to elucidate the effects and safety of probiotics in AD.
We observed an increase in viable S. aureus abundance on sites with increased severity of disease and many virulence factors were expressed at the AD skin sites. Surprisingly, we did not observe any significant upregulation of the virulence factors at the lesional sites compared to the non-lesional control. Overall, we utilized a robust assay...