Recent insights into the management of treatment-resistant pediatric atopic dermatitis
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132517/
Atopic dermatitis (AD) is a prevalent protracted inflammatory skin condition that affects approximately 12% of children globally. Topical remedies, such as pharmacologic and nonpharmacologic management, and off-label systemic medicines, have...
What is new from this article as messages for women and their families?
Treatment resistance in pediatric atopic dermatitis patients can be caused by deficient obedience or inappropriate medicine usage, a shortage of pharmaceuticals, hypersensitivity reciprocation to local application of therapeutics, cutaneous infections, and other...
The role of the skin microbiome in atopic dermatitis - correlations and consequences - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35384293/
The physical barrier function of the skin is significantly supported by the (epi-)dermal immune system and the skin's own microbiome. Atopic dermatitis is characterized by an imbalance of all these...
Overall, the use of topical probiotics is, therefore, an intriguing option for the treatment of AD that should be pursued in larger randomized and controlled studies. In this context, the effects achieved with different bacterial strains seem to be by no means mechanistically redundant. The fact that direct manipulation of the skin microbiome is...
Current and Emerging Strategies to Inhibit Type 2 Inflammation in Atopic Dermatitis - Dermatology and Therapy
Source : https://link.springer.com/article/10.1007/s13555-022-00737-7
Type 2 immunity evolved to combat helminth infections by orchestrating a combined protective response of innate and adaptive immune cells and promotion of parasitic worm destruction or expulsion, wound repair,...
Aberrant type 2 immune responses are associated with allergic conditions characterized by chronic tissue inflammation, including atopic dermatitis.
TLR4 polymorphisms as potential predictors of atopic dermatitis in Chinese Han children - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35349724/
1 Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health, Hangzhou, China. 2 Zhejiang University School of Medicine, Hangzhou, China....
Conclusions: Our data suggested that TLR4 rs11536891 polymorphism was associated with the susceptibility to AD in Chinese Han children. And TLR4 rs7869402 might confer the severity of pediatric AD patients.
Unique gut microbiome signatures among adult patients with moderate to severe atopic dermatitis in southern Chinese
Source : https://doi.org/10.1101/2022.05.14.491964
Imbalance of the immune system caused by alterations of gut microbiome is considered to be a critical factor in the pathogenesis of infant eczema but the exact role of the...
This study provides insights into new therapeutic strategies targeting the gut microbiome for AD and evidence for the involvement of gut-skin axis in AD patients.