Current and Emerging Strategies to Inhibit Type 2 Inflammation in Atopic Dermatitis - Dermatology and Therapy
Source : https://link.springer.com/article/10.1007/s13555-022-00737-7
Type 2 immunity evolved to combat helminth infections by orchestrating a combined protective response of innate and adaptive immune cells and promotion of parasitic worm destruction or expulsion, wound repair,...
Aberrant type 2 immune responses are associated with allergic conditions characterized by chronic tissue inflammation, including atopic dermatitis.
TLR4 polymorphisms as potential predictors of atopic dermatitis in Chinese Han children - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35349724/
1 Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health, Hangzhou, China. 2 Zhejiang University School of Medicine, Hangzhou, China....
Conclusions: Our data suggested that TLR4 rs11536891 polymorphism was associated with the susceptibility to AD in Chinese Han children. And TLR4 rs7869402 might confer the severity of pediatric AD patients.
Unique gut microbiome signatures among adult patients with moderate to severe atopic dermatitis in southern Chinese
Source : https://doi.org/10.1101/2022.05.14.491964
Imbalance of the immune system caused by alterations of gut microbiome is considered to be a critical factor in the pathogenesis of infant eczema but the exact role of the...
This study provides insights into new therapeutic strategies targeting the gut microbiome for AD and evidence for the involvement of gut-skin axis in AD patients.
Longitudinal atopic dermatitis endotypes: An atopic march paradigm that includes Black children - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34673050/
Black and White children with AD have distinct allergic trajectories defined by different longitudinal endotypes. Black children exhibit higher asthma risk despite a more intact skin barrier and less sensitization,...
Conclusions: Black and White children with AD have distinct allergic trajectories defined by different longitudinal endotypes. Black children exhibit higher asthma risk despite a more intact skin barrier and less sensitization, FA, and AR. White children have less asthma risk, despite a more dysfunctional skin barrier, and more FA, AR, and...
Mechanisms and Implications of Bacterial Invasion across the Human Skin Barrier - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35532353/
Atopic dermatitis (AD) is associated with a deficiency of skin lipids, increased populations of Staphylococcus aureus in the microbiome, and structural defects in the stratum corneum (SC), the outermost layer...
Results reveal for the first time that S. aureus can be internalized by corneocytes, indicating transcellular movement through the tissue during permeation, consistent with previous theoretical models. S. aureus also degrades the mechanical integrity of human SC, particularly when the tissue is partially depleted of lipids. These observed...
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Atopic Dermatitis Connect4yrKey Points • Source: Microbiology Spectrum • Conclusion. “When coupled with delipidated AD tissue conditions, bacterial permeation can also explain increased tissue fragility, potentially causing lesion formation in AD patients that results in further Show More