Discovery and Synthesis of Novel Inflammation Reducing Drug for Atopic Dermatitis
Source : https://digitalcommons.imsa.edu/sir_presentations/2022/session1/9/
Atopic dermatitis (AD) is a non-contagious chronic inflammatory skin disease. AD is associated with allergies such as those that pertain to food or dust, allergic asthma, and anaphylaxis. These reactions...
Topical treatments such as topical steroids and PDE4 inhibitors are the most common medication for immediate, on-site treatment of AD to reduce inflammation. However, the Janus-kinase signal transducer was discovered in recent years as a regulator of inflammation and myeloproliferation and may be more effective than current medication in...
Seungmagalgeun-Tang, a Traditional Herbal Formula, Alleviates Skin Inflammation and Depression-Like Behavior in Atopic Dermatitis Mice under Sleep Deprivation Conditions
Source : https://www.hindawi.com/journals/ecam/2022/1307173/
Atopic dermatitis (AD) is a common inflammatory skin disease, which can be worsened under sleep deprivation (SD) conditions. This study investigated the efficacy and the mechanism of action of the...
This study suggests that SMGGT with puerarin and paeoniflorin as main bioactive components alleviates skin inflammation and depression-like behavior in a sleep-deprived mouse model of AD.
Conclusion: Our results highlight the distinctive skin microbiome features of healthy caregivers for children with AD, and support their inclusion in strategies for the treatment of recurrent paediatric AD.
Role of ERK Pathway in the Pathogenesis of Atopic Dermatitis and Its Potential as a Therapeutic Target
Source : https://www.mdpi.com/1422-0067/23/7/3467
Atopic dermatitis (AD) is an eczematous skin disorder characterized by type 2 inflammation, barrier disruption, and intense itch. In addition to type 2 cytokines, many other cytokines, such as interferon...
Topical application of an ERK inhibitor alleviated the clinical symptoms, histological changes, TEWL, and decrease in expression of filaggrin in the AD-like NC/Nga murine model. The ERK inhibitor also restored the IL-4 induced reduction in the expression of filaggrin in NHEK, and inhibited chemokine production from BMDC induced by IL-4. These...
Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: findings from the TMM BirThree Cohort Study - BMC Pregnancy and Childbirth
Source : https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-022-04556-8
Background Maternal mental health problems in each of the prenatal period and postnatal period have been demonstrated as possible risk factors for atopic dermatitis (AD) in children. However, the cumulative...
Conclusions: Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods was associated with the development of AD in children