Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study - Egyptian Pediatric Association Gazette
Source : https://link.springer.com/article/10.1186/s43054-021-00083-x
Background Atopic dermatitis is characterized by impaired skin barrier and altered cutaneous innate immunity. The estimated prevalence among Egyptian children was 10-12%. Several studies suggest that it may be associated...
Conclusion: We found a positive relationship of atopic dermatitis with both diabetes and hyperlipidemia among children, and positive dose-response relationship of several non-traditional biomarkers of C-reactive protein, gamma-glutamyl transferase, and alkaline phosphatase with the presence and severity of atopic dermatitis.
Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life
Source : https://doi.org/10.3390/nu13113779
Atopic eczema, the most common atopic disease in infants, may pave the way for sensitization and allergy later in childhood. Fatty acids have immune-regulating properties and may regulate skin permeability.
Our results suggest that prenatal exposure to unsaturated fatty acids is associated with eczema development in the infant. Maternal diet during pregnancy may partly explain the fatty acid profiles in utero.
Assessment of biomarkers in pediatric atopic dermatitis by tape strips and skin biopsies
Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/all.15153
A M. Andersson , J. Sølberg , A. Koch , L. Skov , I. Jakasa , S. Kezic , J. P. Thyssen , Corresponding Author Department of Dermatology, Bispebjerg Hospital,...
Conclusion: Sampling of the stratum corneum with non-invasive tape strips can be used to identify biomarkers that are associated with disease severity, food allergy and FLG mutations. Skin biopsies showed robust Th2 signature but was inferior for association analysis regarding severity.
Expert Perspectives on Key Parameters that Impact Interpretation of Randomized Clinical Trials in Moderate-to-Severe Atopic Dermatitis - American Journal of Clinical Dermatology
Source : https://link.springer.com/article/10.1007/s40257-021-00639-y
The recent advent of numerous clinical trials for the treatment of moderate-to-severe atopic dermatitis has led to new and emerging therapeutic options for this chronic inflammatory skin disease. With this...
Transcriptomic Analysis of Healthy and Atopic Dermatitis Samples Reveals the Role of IL-37 in Human Skin
Source : https://doi.org/10.4049/immunohorizons.2100055
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects up to one in five children and millions of adults in developed countries. Clinically, AD skin lesions manifest as...
doi:
Addition of Th2 cytokines to the aforementioned in vitro three-dimensional skin model recapitulates key aspects of AD skin and was sufficient to reduce epidermal IL-37 levels. Image analysis also indicated close relationship between epidermal IL-37 and skin epidermal differentiation complex proteins. These findings suggest IL-37 is...