pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis

Source : https://www.jimmunol.org/content/early/2021/06/16/jimmunol.2001363.abstract

pH sensing by GPR65 regulates various inflammatory conditions, but its role in skin remains unknown. In this study, we performed a phenome-wide association study and report that the T allele...

Comorbidities and treatment patterns in adult patients with atopic dermatitis: results from a nationwide multicenter study

Source : https://link.springer.com/article/10.1007/s00403-021-02243-w

Adult atopic dermatitis (adult AD) is a systemic inflammatory disorder, whose relationship with immune-allergic and metabolic comorbidities is not well established yet. Moreover, treatment of mild-to-moderate and severe atopic dermatitis...

Mepolizumab in Patients with Severe Eosinophilic Asthma | JAA

Source : https://doi.org/10.2147/JAA.S298559

Severe asthma is a heterogeneous disease comprising different and overlapping phenotypes driven by distinct pathophysiological processes. These phenotypes are distinguished by clinical characteristics, physiological measures and biomarker expression. Two such...

The IL-4, IL-13 and IL-31 pathways in atopic dermatitis

Source : https://doi.org/10.1080/1744666X.2021.1940962

Abstract Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier defects driving cutaneous inflammation and...

Probiotic mixture reduces gut inflammation and microbial dysbiosis in children with atopic dermatitis

Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/ajd.13644

Wonsuck Yoon , Sang Hyun Park , Jue Seong Lee , Jung Hye Byeon , Seung Hyun Kim , Jaehoon Lim , Young Yoo , Corresponding Author Allergy Immunology Center,...