Noncutaneous and Cutaneous Cancer Risk in Patients With Atopic Dermatitis: A Systematic Review and Meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/31825457/
Observational evidence suggests potential associations between AD and increased risk of keratinocyte carcinoma and kidney cancer as well as lower odds of lung and respiratory system cancers. Further research is needed to address the heterogeneity and limitations of current evidence and to better und ...
Conclusion: Adults with moderate-to-severe AD had a significantly higher risk of developing melanoma (RR 1.11; 95% Cl, 1.05-1.17; p<.001), SCC (RR 1.25; 95% Cl, 1.22-1.28; p<.001), and BCC (RR 1.17; 95% Cl, 1.14-1.20; p<.001) compared to adults with mild AD. In conclusion, our findings support an increased risk of melanoma, SCC, and BCC development in adult patients with AD regardless of AD severity. More mechanistic studies are necessary to understand AD and the development of skin cancers.
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Barbara Honig2yrThese results are consistent with the immune-mediated nature of both autoimmune diseases like AD and certain skin cancers. Also, moderate to severe AD patients may be more skin cancer prone due to increased UV exposure (natural or artificial) used in an attempt to ameliorate their AD symptoms.