Key Points
• Source: Journal of Allergy and Clinical Immunology
• Conclusions/Relevance: “These results highlight severe infant LRTI [lower respiratory tract infection] as an important risk factor for allergic atopic disease, namely poly-sensitization and atopic dermatitis, and suggest that this risk is independent of maternal in utero environment, both-parent history of asthma, and both-parent genetic predisposition.
• The aim of this study was to determine whether clinically defined, moderate-severe lower respiratory tract infections (LRTI) during infancy were correlated with atopic dermatitis and allergic at the time of preschool.
• When compared with children with no history of LRTI during the first 18 months of life, moderate-severe LRTIs predicted poly-sensitization (OR: ; P = .014) and atopic dermatitis (OR: 2.19; P < .001).
• Risk of atopic dermatitis in infants with LRTI before 18 months was independent of genetic predisposition or parent history of asthma.
• One limitation of the current study is that food sensitization was not assessed by oral food challenge testing. Additionally, the investigators did not determine antibiotic use, which could have contributed to the development of atopic dermatitis.
• Source: Journal of Allergy and Clinical Immunology
• Conclusions/Relevance: “These results highlight severe infant LRTI [lower respiratory tract infection] as an important risk factor for allergic atopic disease, namely poly-sensitization and atopic dermatitis, and suggest that this risk is independent of maternal in utero environment, both-parent history of asthma, and both-parent genetic predisposition.
• The aim of this study was to determine whether clinically defined, moderate-severe lower respiratory tract infections (LRTI) during infancy were correlated with atopic dermatitis and allergic at the time of preschool.
• When compared with children with no history of LRTI during the first 18 months of life, moderate-severe LRTIs predicted poly-sensitization (OR: ; P = .014) and atopic dermatitis (OR: 2.19; P < .001).
• Risk of atopic dermatitis in infants with LRTI before 18 months was independent of genetic predisposition or parent history of asthma.
• One limitation of the current study is that food sensitization was not assessed by oral food challenge testing. Additionally, the investigators did not determine antibiotic use, which could have contributed to the development of atopic dermatitis.