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Efficacy and Safety of an Antioxidant-Enriched Medical Device for Topical Use in Adults with Eczematous Dermatitis - Dermatology and Therapy

Efficacy and Safety of an Antioxidant-Enriched Medical Device for Topical Use in Adults with Eczematous Dermatitis - Dermatology and Therapy

Source : https://link.springer.com/article/10.1007/s13555-022-00705-1

Introduction Emollients reduce the severity of dermatitis-associated symptoms. Antioxidant supplementation may be helpful to control inflammatory processes and consequential skin damage. The clinical performance and safety of an emollient medical device for topical treatment enriched with antioxidant ingredients in adults with mild-to-moderate dermatitis is presented in this manuscript.


Conclusion:The medical device studied for topical use in this clinical trial is considered safe and reduces pruritus in adults with atopic and contact dermatitis.

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    Key Points
    • Source: Dermatology and Therapy
    • Conclusion/Relevance: “The medical device studied for topical use in this clinical trial is considered safe and reduces pruritus in adults with atopic and contact dermatitis.”
    • Investigators analyzed the clinical performance and safety of an antioxidant-enriched medical emollient for topical use in 40 adults with mild-to-moderate dermatitis.
    • In 87.5% of participants, treatment was successful at 28 days (P <  ). Participants were satisfied with the treatment and noted a decrease in pruritus severity and an improvement of quality of life (P <  ). At the end of the study, skin conditions improved in more than 90% of individuals, with no safety issues.
    • The addition of antioxidants could target the oxidative stress of atopic dermatitis. Antioxidants could improve emollient actions of moisturizers.
    • “The combination of therapies with nanotechnologies to deliver topicals is emerging as a good strategy to improve patients’ adherence to treatment, particularly during the past 2 years in which many patients struggled to continue their routines and daily treatments owing to the COVID-19 pandemic,” the authors wrote. “This clinical study highlights the importance of addressing the interplay of multiple pathogenesis factors of barrier dysfunction, pruritus/inflammation, dysfunctional immune response, and oxidative stress as a new treatment target in dermatitis.”
    • Limitations of the current study include the open-label design and the paucity of a control group.

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