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Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomised controlled trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35763390/
Our data provide the first randomised controlled trial evidence of a protective effect of antenatal cholecalciferol supplementation on risk of infantile atopic eczema, with the effect potentially being via increased breast milk cholecalciferol levels. The findings support a developmental influence o ...
Conclusion: Our data provide the first randomised controlled trial evidence of a protective effect of antenatal cholecalciferol supplementation on risk of infantile atopic eczema, with the effect potentially being via increased breast milk cholecalciferol levels.
• Source: British Journal of Dermatology
• Relevance: “Our data provide the first randomised controlled trial evidence of a protective effect of antenatal cholecalciferol supplementation on risk of infantile atopic eczema, with the effect potentially being via increased breast milk cholecalciferol levels. The findings support a developmental influence on atopic eczema, and point to a potentially modifiable perinatal influence on atopic eczema.”
• Researchers mined data from the UK Maternal Vitamin D Osteoporosis Study (MAVIDOS), which was a double-blind, randomized, placebo-controlled trial. They assessed the effects of cholecalciferol supplementation, which was taken starting at 14 weeks gestation, in babies at 12, 24, and 48 months.
• After compensating for breastfeeding length, mothers who took 1000 IUM cholecalciferol daily exhibited lower OR at 12 months (OR ; P =0.04), with this outcome weakened and non-significant at 24 and 48 months. The effect was present in infants fed for 1+ months only and not for less than a month.