Extracellular matrix and dermal nerve growth factor dysregulation in prurigo nodularis compared to atopic dermatitis
Source : https://www.frontiersin.org/articles/10.3389/fmed.2022.1022889/abstract
Prurigo nodularis (PN) is a chronic, pruritic, inflammatory skin disease characterized by hyperkeratotic nodules on the trunk and extremities. While there is growing research on the immunological basis of PN, the neuropathic and structural components of PN lesions are unknown.
Conclusions: We present novel findings demonstrating increased neurotrophic and extracellular matrix remodeling signatures in PN compared to AD, possibly explaining the morphological differences in their lesions. These signatures may therefore be important components of the PN pathogenesis and may serve as therapeutic targets.
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Jeremy Moss, Medical director and physician3yrI'm so glad research is now focusing on this troubling and difficult to treat condition. We now have our first approved medicine for PN. I hope that through more research such as this, further therapeutic options can be developed for these patients.
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Barbara Honig3yrA useful approach to help determine best MOA to address this debilitating disease. IL 31 show much promise in PN.