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Extracellular matrix and dermal nerve growth factor dysregulation in prurigo nodularis compared to atopic dermatitis

Source : https://www.frontiersin.org/articles/10.3389/fmed.2022.1022889/abstract

Prurigo nodularis (PN) is a chronic, pruritic, inflammatory skin disease characterized by hyperkeratotic nodules on the trunk and extremities. While there is growing research on the immunological basis of PN, the neuropathic and structural components of PN lesions are unknown.

  • 2yr
    I'm so glad research is now focusing on this troubling and difficult to treat condition. We now have our first approved medicine for PN. I hope that through more research such as this, further therapeutic options can be developed for these patients.
  • 2yr
    A useful approach to help determine best MOA to address this debilitating disease. IL 31 show much promise in PN.