Management of Atopic Dermatitis: The Role of Tacrolimus
Source : https://www.cureus.com/articles/110814-management-of-atopic-dermatitis-the-role-of-tacrolimus
Atopic dermatitis (AD) is a long-lasting inflammatory dermatological condition characterized by itchy, eczematous, sparsely tiny blisters that hold a clear watery substance. Additionally, the diseased skin can suppurate, occasionally with...
Conclusion: It was evident from the available trials, systematic reviews, and other studies that tacrolimus is equi-efficacious to glucocorticoids in ameliorating AD symptoms. Except for skin irritation or burning sensation, the safety profile of tacrolimus is similar to that of corticosteroids.
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Atopic Dermatitis Connect3yrKey Points • Source: Cureus • Conclusion/Relevance: “Tacrolimus belongs to the class of calcineurin inhibitors, which is a type of immunomodulator possessing promising efficacy in treating AD. Topical tacrolimus is an effective and safe Show More
Cold Plasmamed Beam as a Supporting Treatment of Soft Tissue Injuries | MDER
Cold plasma is a mixture of many components: charge carriers (ions, electrons), free radicals and active substances, electromagnetic fields, temperature, visible light, and ultraviolet rays. The synergistic effect of these...
Conclusion: The study emphasizes that irradiation with cold plasma contributes to the wound healing process, including in AD.
Safety and Efficacy of Dupilumab for the Treatment of Hospitalized Patients With Moderate to Severe Coronavirus Disease 2019: A Phase 2a Trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35959207/
1 Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA. 2 Department of Public Health Sciences, University of Virginia School of...
Conclusion: Although the primary outcome of day 28 ventilator-free survival was not reached, adverse events were not observed and survival was higher in the dupilumab group by day 60.
Influence of the early-life gut microbiota on the immune responses to an inhaled allergen - Mucosal Immunology
Source : https://www.nature.com/articles/s41385-022-00544-5
Antibiotics, among the most used medications in children, affect gut microbiome communities and metabolic functions. These changes in microbiota structure can impact host immunity. We hypothesized that early-life microbiome alterations...
These studies indicate that early-life microbiota composition can heighten allergen-driven Th2/Th17 immune pathways and airway responses in an age-dependent manner.
Early Exposure to Antibiotics Can Cause Permanent Asthma and Allergies
Source : https://www.rutgers.edu/news/early-exposure-antibiotics-can-cause-permanent-asthma-and-allergies
The study, published in Mucosal Immunology , has provided the strongest evidence so far that the long-observed connection between antibiotic exposure in early childhood and later development of asthma and...
Blaser added that “these experiments provide strong evidence that antibiotics cause unwanted immune responses to develop via their effect on gut bacteria, but only if gut bacteria are altered in early childhood.”