Conclusion: These data suggest that in utero epigenetic and transcriptomic mechanisms predominantly involving the interferon pathway can impact development of infant atopy.
Evaluation of Atopic Dermatitis Improvement Caused by Low-Level, Low-Frequency Pulsed Electromagnetic Fields - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35476222/
This study aimed to evaluate the effectiveness of using low-level, low-frequency pulsed electromagnetic field (LLLF_PEMF) stimulation to improve atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNCB). Twenty 6-week-old hairless mice were randomly...
Sensory evaluation analysis revealed a significant difference between the PEMF 15 Hz group and Sham group (P
Results suggest that distinctions in innervation density in the epidermis vs dermis in association with MCs may underlie scratching behaviors that contribute to AD progression and could reveal novel treatment strategies for AD.
Psychological Interventions Are More Effective Than Educational Interventions at Improving Atopic Dermatitis Severity: A Systematic Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35481826/
doi: 10.1097/DER.0000000000000868. Online ahead of print. 1 Department of Psychiatry, University of Illinois at Chicago. 2 Department of Dermatology, University of Illinois at Chicago College of Medicine. 3 Department of...
The most commonly studied psychological intervention was habit reversal training (8/11 studies), which was most frequently incorporated in studies that reduced AD severity (8/10 studies). The most commonly studied educational interventions were education on AD triggers (7/7 studies) and skin care (7/7 studies); they were incorporated in all...
A review of IL-36: an emerging therapeutic target for inflammatory dermatoses
Source : https://doi.org/10.1080/09546634.2022.2067819
Abstract IL-36 cytokines are members of the IL-1 superfamily. Increasing evidence in the IL-36 pathway demonstrates their potential as a therapeutic target for treating inflammatory skin diseases, such as generalized...
Molecular changes associated with abnormal immune responses and the epidermal barrier in children with mild-to-moderate AD can be determined using the SSL-RNA method. This non-invasive method could therefore be a useful means for understanding the molecular pathology of paediatric AD.