Non-invasive transcriptomic analysis using mRNAs in skin surface lipids obtained from children with mild-to-moderate atopic dermatitis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35462437/
Molecular changes associated with abnormal immune responses and the epidermal barrier in children with mild-to-moderate AD can be determined using the SSL-RNA method. This non-invasive method could therefore be a...
Conclusions: Molecular changes associated with abnormal immune responses and the epidermal barrier in children with mild-to-moderate AD can be determined using the SSL-RNA method. This non-invasive method could therefore be a useful means for understanding the molecular pathology of paediatric AD.
Differences in Occurrence, Risk Factors and Severity of Early-onset Atopic Dermatitis among Preterm and Term Children - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35470403/
This prospective birth cohort followed 150 preterm and 300 term newborns during the first year of life to assess possible differences in risk factors, age at onset, anatomical location, and...
Atopic dermatitis during the first year of life was observed in 21.2% of children and was more common in term children compared with preterm children (26.7% vs 11.7%, p
Increasing severity of early-onset atopic dermatitis, but not late-onset, associates with development of aeroallergen sensitization and allergic rhinitis in childhood - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34558075/
1 COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. 2 Department of Pediatrics, Slagelse Sygehus, Slagelse, Denmark. Background: Early exposure to...
Conclusion: Increasing severity of early-onset AD, but not late-onset AD, associates with aeroallergen sensitization and allergic rhinitis later in childhood.
Obstructive sleep apnea in patients with severe asthma: Prevalence and association between severity and asthma control Al-Lawati F, Al-Mubaihsi SM, Jayakrishnan B, Rizvi S, Al-Abri MA - Ann Thorac Med
ORIGINAL ARTICLE Year : 2022 | Volume : 17 | Issue : 2 | Page : 118-123 Obstructive sleep apnea in patients with severe asthma: Prevalence and association between severity...
Conclusions: The prevalence of OSA was high (32.37%) in patients with severe asthma. Uncontrolled severe asthma was significantly associated with severe OSA.
A Maximum-Use Trial of Ruxolitinib Cream in Adolescents and Adults with Atopic Dermatitis - American Journal of Clinical Dermatology
Source : https://link.springer.com/article/10.1007/s40257-022-00690-3
Background Ruxolitinib cream is a topical formulation of ruxolitinib, an inhibitor of Janus kinase 1 and Janus kinase 2. Objective We aimed to determine the safety, tolerability, and bioavailability of...
Conclusions: Under maximum-use conditions, ruxolitinib cream was generally well tolerated, with approximately one-third of patients experiencing treatment-emergent adverse events and few treatment-related adverse events. The mean steady-state plasma concentration of ruxolitinib was well below the level expected to affect bone marrow production...