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3yr
Role of ERK Pathway in the Pathogenesis of Atopic Dermatitis and Its Potential as a Therapeutic Target

Role of ERK Pathway in the Pathogenesis of Atopic Dermatitis and Its Potential as a Therapeutic Target

Source : https://www.mdpi.com/1422-0067/23/7/3467

Atopic dermatitis (AD) is an eczematous skin disorder characterized by type 2 inflammation, barrier disruption, and intense itch. In addition to type 2 cytokines, many other cytokines, such as interferon...


Topical application of an ERK inhibitor alleviated the clinical symptoms, histological changes, TEWL, and decrease in expression of filaggrin in the AD-like NC/Nga murine model. The ERK inhibitor also restored the IL-4 induced reduction in the expression of filaggrin in NHEK, and inhibited chemokine production from BMDC induced by IL-4. These...

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3yr
Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: findings from the TMM BirThree Cohort Study - BMC Pregnancy and Childbirth

Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: findings from the TMM BirThree Cohort Study - BMC Pregnancy and Childbirth

Source : https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-022-04556-8

Background Maternal mental health problems in each of the prenatal period and postnatal period have been demonstrated as possible risk factors for atopic dermatitis (AD) in children. However, the cumulative...



Conclusions: Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods was associated with the development of AD in children

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3yr

Mitochondrial activity is up-regulated in nonlesional atopic dermatitis and amenable to therapeutic intervention.

Source : https://doi.org/10.1016/j.jid.2022.01.035


Treatment of ADNL HEEs with Tigecycline or MitoQ largely corrected the AD profile, including high p-65NF-κB, abnormal lamellar bodies and cellular damage. Furthermore, we found that glycolysis supports but does not supersede mitochondrial metabolism in ADNL KCs. Thus, aerobic metabolism predominates in ADNL but leads to oxidative stress....

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3yr
Day 3 Highlights from the 2022 American Academy of Dermatology Annual Meeting

The American Academy of Dermatology’s 2022 annual meeting offered a look at what’s new in dermatology, from late-breaking research to controversies in care. In numerous sessions covering a variety of topics, experts in the field examined how dermatologists can help manage Merkel cell carcinoma, suspicious moles and melanoma in pregnancy, the challenge of using laser treatments on Asian skin, the latest news on advances in psoriasis treatment, and what’s new with JAK inhibitors.



Click on the image above to view selected highlights from our team of analysts.


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3yr
Day 3 Highlights from the 2022 American Academy of Dermatology Annual Meeting

The American Academy of Dermatology’s 2022 annual meeting offered a look at what’s new in dermatology, from late-breaking research to controversies in care. In numerous sessions covering a variety of topics, experts in the field examined how dermatologists can help manage Merkel cell carcinoma, suspicious moles and melanoma in pregnancy, the challenge of using laser treatments on Asian skin, the latest news on advances in psoriasis treatment, and what’s new with JAK inhibitors.

Click on the image above to view selected highlights from our team of analysts.