Aeroallergens in Atopic Dermatitis and Chronic Urticaria - Current Allergy and Asthma Reports
Source : https://link.springer.com/article/10.1007/s11882-022-01033-2
Purpose of Review While aeroallergens are a well-established trigger of asthma and allergic rhinitis, their role in allergic skin diseases such as atopic dermatitis and chronic urticaria remains controversial. This...
Summary: The role of aeroallergens as a trigger is clear in atopic dermatitis and becoming emergent in chronic urticaria. Skin prick testing or serum-specific immunoglobulin E testing may be used to determine sensitivities. Management at this time centers on avoidance, and further studies are necessary to evaluate the efficacy of aeroallergen...
Immunomodulatory Role of Staphylococcus aureus in Atopic Dermatitis
Source : https://doi.org/10.3390/pathogens11040422
Staphylococcus aureus is a gram-positive bacterium commonly found on humans, and it constitutes the skin microbiota. Presence of S. aureus in healthy individuals usually does not pose any threat, as...
Until recently, IL-36 had been found to play an important role in modulating atopic dermatitis. Secretion of IL-36 from keratinocytes can activate a Th2 independent pathway to trigger symptoms of allergic reaction resulting in clinical manifestations. This mini review aims to summarize the immunomodulatory roles of S. aureus virulence factors...
Discovery and Synthesis of Novel Inflammation Reducing Drug for Atopic Dermatitis
Source : https://digitalcommons.imsa.edu/sir_presentations/2022/session1/9/
Atopic dermatitis (AD) is a non-contagious chronic inflammatory skin disease. AD is associated with allergies such as those that pertain to food or dust, allergic asthma, and anaphylaxis. These reactions...
Topical treatments such as topical steroids and PDE4 inhibitors are the most common medication for immediate, on-site treatment of AD to reduce inflammation. However, the Janus-kinase signal transducer was discovered in recent years as a regulator of inflammation and myeloproliferation and may be more effective than current medication in...
Seungmagalgeun-Tang, a Traditional Herbal Formula, Alleviates Skin Inflammation and Depression-Like Behavior in Atopic Dermatitis Mice under Sleep Deprivation Conditions
Source : https://www.hindawi.com/journals/ecam/2022/1307173/
Atopic dermatitis (AD) is a common inflammatory skin disease, which can be worsened under sleep deprivation (SD) conditions. This study investigated the efficacy and the mechanism of action of the...
This study suggests that SMGGT with puerarin and paeoniflorin as main bioactive components alleviates skin inflammation and depression-like behavior in a sleep-deprived mouse model of AD.
Conclusion: Our results highlight the distinctive skin microbiome features of healthy caregivers for children with AD, and support their inclusion in strategies for the treatment of recurrent paediatric AD.