VitaminD tolerance activation in dendritic cells
Source : https://www.carrerasresearch.org/en/vitamind-tolerance-activation-in-dendritic-cells_197433
Researchers at the Josep Carreras Leukaemia Research Institute and the Germans Trias i Pujol Hospital discover the epigenetic mechanism by which vitamin D promotes tolerogenic characteristics in dendritic cells, key...
Thus, the researchers manage to demonstrate, for the first time, that the relationship between vitamin D and the generation of the tolerance profile of dendritic cells is due to the modification of epigenetic marks by TET2, through the IL-6- JAK-STAT3, very well-known clinical target.
Microbial dysbiosis in a mouse model of atopic dermatitis mimics shifts in human microbiome and correlates with the key pro‐inflammatory cytokines IL‐4, IL‐33 and TSLP
Source : https://doi.org/10.1111/jdv.17911
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between...
Conclusions: In this article we show that i) the model of choice to investigate AD needs to be characterized for the cutaneous microbiota if applicable and ii) the oxazolone-mediated mixed Th1-Th2 immune response triggers microbiota-induced alterations which share similarities to dysbiosis in human AD and represents therefore a suitable model...
Highlights
- Personalized therapy will evolve
- Each nanocarrier type’s unique features assist AD mitigation
- Existing animal models must be reviewed
Clinico-biochemical relation of Vitamin D3 with the severity of atopic dermatitis and response to supplementation of Vitamin D3: A randomized controlled trial
Source : https://mansapublishers.com/IJCH/article/view/3227
https://doi.org/10.32677/ijch.v8i12.3227 Atopy, Eczema, Vitamin D3, SCORAD, Pediatric Background: Atopic dermatitis (AD), also known as eczema, is one of the most common skin disorders among children and adults, with a steep...
Conclusion: Short-term therapeutic supplementation of Vitamin. D3 in children with moderate to severe AD improves the clinical score. There is an inverse relationship between serum Vitamin. D3 level and severity of AD.
Conclusion: A majority of existing literature confirmed a connection between low serum vitamin D levels and worsening of allergic reactions. However, there is weak evidence that supplementation (Cholecalciferol - 1000 IU) can improve these conditions. Further research needs to be conducted in order to establish the dose of Cholecalciferol for...