micro-community-banner
 
  • Saved

4yr
Accurate diagnosis of atopic dermatitis by combining transcriptome and microbiota data with supervised machine learning - Scientific Reports

Accurate diagnosis of atopic dermatitis by combining transcriptome and microbiota data with supervised machine learning - Scientific Reports

Source : https://www.nature.com/articles/s41598-021-04373-7

Atopic dermatitis (AD) is a common skin disease in childhood whose diagnosis requires expertise in dermatology. Recent studies have indicated that host genes-microbial interactions in the gut contribute to human...


Although further replications in other cohorts are needed, our findings suggest that these genes and microbiota features may provide novel biological insights and may be developed into useful biomarkers of AD prediction.

  • Saved

4yr
Mild to moderate atopic dermatitis severity can be reliably assessed using smartphone-photographs taken by the patient at home: A validation study - PubMed

Mild to moderate atopic dermatitis severity can be reliably assessed using smartphone-photographs taken by the patient at home: A validation study - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35020960/

doi: 10.1111/srt.13136. Online ahead of print. 1 Department of Dermatology and Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark. 2 OMHU A/S, Copenhagen, Denmark. 3 Studies&Me A/S, Copenhagen, Denmark. 4 Colentina...


Conclusion: There was high agreement between mild to moderate AD severity assessed clinically and based on smartphone photographs. Further, the photographic assessments can be reproduced with high reliability.

  • Saved

4yr
Multi-omics-based identification of atopic dermatitis target genes and their potential associations with metabolites and miRNAs

Multi-omics-based identification of atopic dermatitis target genes and their potential associations with metabolites and miRNAs

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748113/

Atopic dermatitis (AD), or atopic eczema, is one of the most common inflammatory skin diseases with up to 10% prevalence in adults, and approximately 15-20% in children in industrialized countries....


Our results revealed potential novel associations between fatty acids and peroxisomal lipid metabolism pathways, as well as with several microRNAs.

  • Saved

4yr

Moderate-severe lower respiratory tract infection in early-life is associated with increased risk of poly-sensitization and atopic dermatitis: findings from the CHILD Study

Source : https://doi.org/10.1016/j.jacig.2021.12.005

  • 4yr
    Key Points • Source: Journal of Allergy and Clinical Immunology • Conclusions/Relevance: “These results highlight severe infant LRTI [lower respiratory tract infection] as an important risk factor for allergic atopic disease, namely poly-sensitization and Show More
  • Saved

4yr
From structure to sequence: Antibody discovery using cryoEM

From structure to sequence: Antibody discovery using cryoEM

Source : https://www.science.org/doi/10.1126/sciadv.abk2039

One of the rate-limiting steps in analyzing immune responses to vaccines or infections is the isolation and characterization of monoclonal antibodies. Here, we present a hybrid structural and bioinformatic approach...


When combined with next-generation sequencing of immune repertoires, we were able to specifically identify clonal family members, synthesize the monoclonal antibodies, and confirm that they interact with the antigen in a manner equivalent to the corresponding polyclonal antibodies. This structure-based approach for identification of monoclonal...