Atopic Dermatitis Connect
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4yr

Respiratory syncytial virus specific immunoglobulin G4 antibodies and atopic diseases in children.

Source : https://europepmc.org/article/med/35166484

Background It has been proposed that RSV infection stimulates RSV specific IgE and IgG4 production as a hallmark of Th2 immune response, which can contribute to the development of allergic...


Conclusions: RSV specific IgG4 antibodies could be a marker of risk for the development of atopic sensitization to inhaled and food allergens, development of food allergy and atopic dermatitis in atopic children.

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4yr

Sensitizing agents found in children and adolescents with recalcitrant atopic dermatitis: a cross-sectional study with a pediatric battery

Source : https://doi.org/10.1016/j.abd.2021.08.005


Conclusions:A proportion of patients with recalcitrant atopic dermatitis may be sensitized to different allergens and may even have developed allergic contact dermatitis. Recognizing this context is important in the prevention strategy and management of the disease.

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4yr
Immunomodulatory Effect of Epidermal Growth Factor Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells on Atopic Dermatitis - PubMed

Immunomodulatory Effect of Epidermal Growth Factor Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells on Atopic Dermatitis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35220283/

doi: 10.15283/ijsc21173. Online ahead of print. 1 Stem Cell and Regenerative Bioengineering Institute, Global R&D Center, Kangstem Biotech Co., Ltd., Seoul, Korea. 2 Adult Stem Cell Research Center, Research Institute...


Conclusions: EGF secreted by hUCB-MSCs can improve AD by regulating inflammatory responses of keratinocytes, Th2 cells, and mast cells.


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4yr

A new ex vivo skin model for mechanistic understanding of putative anti-inflammatory topical therapeutics

Source : https://doi.org/10.1016/j.ijpharm.2022.121610


Highlights:
•Human ex vivo skin culture can be stimulated with cytokine cocktails to induce specific T cell mediated inflammatory states.
•The induced inflammatory state in HESC incorporates multiple immune cell pathways as well as chemokine and cell barrier function gene signaling.
•Gene expression profiles elicited in the HESC...

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4yr

Blood transcriptome profiling identifies two candidate endotypes of atopic dermatitis

Source : https://doi.org/10.1016/j.jaci.2022.02.001


Conclusion: Our observations indicate that AD can be stratified into eosinophilic and non-eosinophilic endotypes and might be an incentive for stratified trial designs and treatment strategies.


  • 4yr
    Would be interested in seeing where this go and looking ahead and subtypes of eosinophilic and non-eosinophilic endotypes and treatment implications
  • 4yr
    Key Points • Source: The Journal of Allergy and Clinical Immunology • Conclusion/Relevance: “Our observations indicate that AD [atopic dermatitis] can be stratified into eosinophilic and non-eosinophilic endotypes and might be an incentive for Show More