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Topical JAK Inhibitors for Atopic Dermatitis

Atopic dermatitis (AD), also known as atopic eczema, is a chronic, pruritic, relapsing inflammatory dermatological condition. Early disease management includes moisturizers, avoiding the factors that trigger AD, and patient education. Treatment mainly aims at reducing itch and inflammation, eliminating flare-ups, and reducing side effects.



Topical agents are considered as a primary treatment for mild to moderate AD and include topical corticosteroids (TCS), topical calcineurin inhibitors (TCI), and phosphodiesterase 4 (PDE4) inhibitor. More recently, the first topical selective Janus kinase (JAK)1/JAK2 inhibitor has been approved for use in patients with mild to moderate disease.




  • How will the availability of a topical selective JAK impact your use of TCS, TCI, or PDE4 in mild to moderate AD patients?

  • In which types of patients do you foresee the greatest utility of a topical selective JAK in the treatment of mild to moderate AD patients?


  • 3yr
    Topical JAKs will play a significant role in treating AD patients of all severities because of their efficacy that appears to be substantially better than other non-steroid topicals like TCIs Show More
  • 3yr
    I don't think topical JAKs have been a game changer in mild to moderate AD - unfortunately in part because most insurance plans don't seem to cover them well without Show More

Show More Comments

  • Saved
Topical JAK Inhibitors for Atopic Dermatitis

Atopic dermatitis (AD), also known as atopic eczema, is a chronic, pruritic, relapsing inflammatory dermatological condition. Early disease management includes moisturizers, avoiding the factors that trigger AD, and patient education. Treatment mainly aims at reducing itch and inflammation, eliminating flare-ups, and reducing side effects.



Topical agents are considered as a primary treatment for mild to moderate AD and include topical corticosteroids (TCS), topical calcineurin inhibitors (TCI), and phosphodiesterase 4 (PDE4) inhibitor. More recently, the first topical selective Janus kinase (JAK)1/JAK2 inhibitor has been approved for use in patients with mild to moderate disease.




  • How will the availability of a topical selective JAK impact your use of TCS, TCI, or PDE4 in mild to moderate AD patients?

  • In which types of patients do you foresee the greatest utility of a topical selective JAK in the treatment of mild to moderate AD patients?


  • 3yr
    Topical JAKs will play a significant role in treating AD patients of all severities because of their efficacy that appears to be substantially better than other non-steroid topicals like TCIs Show More
  • 3yr
    I don't think topical JAKs have been a game changer in mild to moderate AD - unfortunately in part because most insurance plans don't seem to cover them well without Show More

Show More Comments

  • Saved
Topical JAK Inhibitors for Atopic Dermatitis

Atopic dermatitis (AD), also known as atopic eczema, is a chronic, pruritic, relapsing inflammatory dermatological condition. Early disease management includes moisturizers, avoiding the factors that trigger AD, and patient education. Treatment mainly aims at reducing itch and inflammation, eliminating flare-ups, and reducing side effects.



Topical agents are considered as a primary treatment for mild to moderate AD and include topical corticosteroids (TCS), topical calcineurin inhibitors (TCI), and phosphodiesterase 4 (PDE4) inhibitor. More recently, the first topical selective Janus kinase (JAK)1/JAK2 inhibitor has been approved for use in patients with mild to moderate disease.




  • How will the availability of a topical selective JAK impact your use of TCS, TCI, or PDE4 in mild to moderate AD patients?

  • In which types of patients do you foresee the greatest utility of a topical selective JAK in the treatment of mild to moderate AD patients?


  • 3yr
    Topical JAKs will play a significant role in treating AD patients of all severities because of their efficacy that appears to be substantially better than other non-steroid topicals like TCIs Show More
  • 3yr
    I don't think topical JAKs have been a game changer in mild to moderate AD - unfortunately in part because most insurance plans don't seem to cover them well without Show More

Show More Comments

  • Saved
Topical JAK Inhibitors for Atopic Dermatitis

Atopic dermatitis (AD), also known as atopic eczema, is a chronic, pruritic, relapsing inflammatory dermatological condition. Early disease management includes moisturizers, avoiding the factors that trigger AD, and patient education. Treatment mainly aims at reducing itch and inflammation, eliminating flare-ups, and reducing side effects.



Topical agents are considered as a primary treatment for mild to moderate AD and include topical corticosteroids (TCS), topical calcineurin inhibitors (TCI), and phosphodiesterase 4 (PDE4) inhibitor. More recently, the first topical selective Janus kinase (JAK)1/JAK2 inhibitor has been approved for use in patients with mild to moderate disease.




  • How will the availability of a topical selective JAK impact your use of TCS, TCI, or PDE4 in mild to moderate AD patients?

  • In which types of patients do you foresee the greatest utility of a topical selective JAK in the treatment of mild to moderate AD patients?


  • 3yr
    Topical JAKs will play a significant role in treating AD patients of all severities because of their efficacy that appears to be substantially better than other non-steroid topicals like TCIs Show More
  • 3yr
    I don't think topical JAKs have been a game changer in mild to moderate AD - unfortunately in part because most insurance plans don't seem to cover them well without Show More

Show More Comments

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The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis

The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis

Source : https://doi.org/10.3390/jcm11195633

Atopic dermatitis (AD) is a common inflammatory skin disease with a complex pathophysiology, intertwining immune dysregulation, epidermal barrier dysfunction, IgE sensitization, environmental factors and genetic predisposition. It has been recently...


Conclusion: Advances in understanding IL-4/IL-13 pathway have opened the way for the development of novel therapeutic agents that target important steps of those signaling cascades. Most importantly, monoclonal antibodies that inhibit the IL-4/IL-13 pathway have revolutionized the treatment of moderate-to-severe AD. In this context, JAK...

  • 3yr
    A number of lines of experimental evidence over the years have suggested that IL-4 and -13 are key cytokines of the Th2 immune system and are important mediators of atopic Show More
  • 3yr
    Clearly, dupixent has revolutionized the treatment of moderate to severe AD. I am also seeing excellent results using rinvoq in AD, and I suspect that the JAK-STAT effect on the Show More