A fragment of type VI collagen alpha-6 chain is elevated in serum from patients with atopic dermatitis, psoriasis, hidradenitis suppurativa, systemic lupus erythematosus and melanoma - Scientific Reports
Source : https://www.nature.com/articles/s41598-023-28746-2
Extracellular matrix (ECM) remodeling of the skin is a continuous process necessary for maintaining tissue homeostasis. Type VI collagen (COL6) is characterized as a beaded filament, located in the dermal...
Conclusions: Cohort 2 confirmed C6A6 being upregulated in atopic dermatitis compared to healthy controls (p
Overall and Racial and Ethnic Subgroup Prevalences of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36857044/
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Conclusions: The findings of this cross-sectional study suggest that there is a significant burden of AA, AT, and AU in the US in which people of color, particularly Asian Americans, appear to be disproportionately affected.
Keratinocyte signaling in atopic dermatitis: investigations in organotypic skin models towards clinical application - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36841264/
A multitude of pathophysiological mechanisms contribute to atopic dermatitis (AD), the most common chronic inflammatory skin disease in the Western population. In the booming therapeutic market for AD, most small...
Discussion: Here, we highlight key evidence that keratinocytes represent major contributors to AD, including disease onset and progression through the physical, immunological and antimicrobial barrier functions of human skin. Examples are provided of pre-clinical skin models recapitulating features of AD in which keratinocyte-specific genetic,...
Discussion: These findings suggest changes in the diagnosing of eczema among racial and ethnic minority groups. In a 2019 study, African genetic ancestry was not associated with risk of atopic dermatitis compared with European ancestry, suggesting that contextual variables such as socioeconomic status, environment, and health care access...
Food Allergy in Preschoolers: Parents' Perception and Self-Reported Prevalence
Background: Food allergy is a potentially fatal condition (in the case of anaphylaxis, for example) and is characterized by an increasing prevalence. The main purpose of this study is to...
Conclusions: Food reaction and/or allergy were reported in 11.2% of children. History of parents’ and siblings’ food allergies and children’s atopic dermatitis had statistically significant associations with the occurrence of food reaction and/or allergy in chidlren, which shows that it may be an important factor to consider.